NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
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- 作者：Raffaele Cerutti1 ; 8 ; Eija Pirinen2 ; 3 ; Costanza Lamperti1 ; Silvia Marchet1 ; Anthony A. Sauve4 ; Wei Li4 ; Valerio Leoni5 ; Eric A. Schon6 ; Franç ; oise Dantzer7 ; Johan Auwerx2 ; Carlo Viscomi1 ; 8 ; cfv23@mrc-mbu.cam.ac.uk" class="auth_mail ; Massimo Zeviani1 ; 8 ; mdz21@mrc-mbu.cam.ac.uk" class="auth_mail
- 刊名：Cell Metabolism
- 出版年：3 June 2014
- 年：2014
- 卷：19
- 期：6
- 页码：1042-1049
- 全文大小：2268 K
文摘
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NAD+ is a substrate activator of Sirtuin 1, a key player of mitochondrial biogenesis
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Parp1 inhibitors and nicotinamide riboside increase the NAD+ content in tissues
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These compounds improve the phenotype of a mitochondrial disease mouse model
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These are potential therapies for human mitochondrial disorders