Clinical Characteristics and Outcomes of Patients with Amphetamine-Associated Cardiomyopathy in South Auckland, New Zealand

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• 作者：Shaw-Hua (Anthony) Kueh ; MBChB ; Ruvin S. Gabriel ; MBChB ; Mayanna Lund ; MBChB ; Tim Sutton ; MBChB ; Joshua Bradley ; MBChB ; Andrew J. Kerr ; MBChB ; Jen-Li Looi ; MBChB ; ^{JenLi.Looi@middlemore.co.nz" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cardiomyopathy ; Heart failure ; Amphetamine ; Echocardiography ; Cardiogenic shock ; Pathophysiology
• 刊名：Heart, Lung and Circulation
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：25
• 期：11
• 页码：1087-1093
• 全文大小：384 K

文摘

Amphetamine-associated cardiomyopathy (AAC) is becoming an increasingly recognised entity. The characteristics and outcomes of these patients are poorly understood.

Methods

Thirty patients admitted with heart failure and echocardiographic evidence of cardiomyopathy between 2005 and 2014 and who had a documented history of amphetamine abuse that was considered an important factor in the causation of their cardiomyopathy were retrospectively identified.

Results

Mean age at presentation was 40±10 years with a male predominance (n=25, 83%). The majority were of indigenous Maori ethnicity. At presentation, four patients were in cardiogenic shock. Five patients required intensive care unit (ICU) admission for inotropic support and mechanical ventilation. Fifteen had severe left ventricular (LV) dilation (mean LV end-diastolic dimension 6.8±1.0 cm) and all patients had severe LV dysfunction (mean LV ejection fraction 22±8%).

Despite optimal heart failure therapy, LV size remained significantly dilated with minimal improvement in LV function. During median follow-up of 18 months, five patients died from end-stage heart failure and 17 had at least one readmission with decompensated heart failure.

Conclusion

Amphetamine-associated cardiomyopathy was seen predominantly in young indigenous Maori men. They presented with severe cardiomyopathy, often requiring ICU admission. Severe LV dilation and significant LV dysfunction persisted despite treatment and mortality was high.