Clinical profile and containment of the Ebola virus disease outbreak in two large West African cities, Nigeria, July-September 2014

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• 作者：Chima Ohuabunwo^a ; ^b ; ^{cohuabunwo@msm.edu} ; ^{flcandi@gmail.com} ; Celestine Ameh^c ; Oyin Oduyebo^d ; Anthony Ahumibe^c ; Bamidele Mutiu^e ; Adebola Olayinka^c ; ^f ; Wasiu Gbadamosi^g ; Erika Garcia^h ; Carolina Nanclaresⁱ ; Wale Famiyesin^j ; Abdulaziz Mohammed^c ; Patrick Nguku^a ; ^c ; Richard I. Koko^j ; Joshua Obasanya^k ; Durojaye Adebayo^k ; Yemi Gbadegesin^k ; Oni Idigbe^l ; Olukayode Oguntimehin^m ; Sara Nyantiⁿ ; Charles Nzukiⁿ ; Ismail Abdus-Salam^o ; Joseph Adeyemi^p ; Nnanna Onyekwere^q ; Emmanuel Musa^j ; David Brett-Major^h ; Faisal Shuaibⁿ ; Abdulsalami Nasidi^k
• 关键词：Ebola virus disease ; Outbreak containment ; Clinical profile ; Hemorrhagic fever ; Gastroenteritis ; Nigeria
• 刊名：International Journal of Infectious Diseases
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：53
• 期：Complete
• 页码：23-29
• 全文大小：786 K
• 卷排序：53

文摘

The outbreak, mostly a severe febrile gastroenteritis syndrome (85% fever, 70% fatigue, 65% diarrhea, 50% vomiting), was in keeping with the West Africa Ebola virus disease pattern.. It began in Africa's most populous city and spread to another large city, but involved only 20 cases, mostly females and health workers; no case management worker was infected. The case fatality rate was low at 40%. A higher mortality was seen in males, those in the older age group (≥40 years), patients with diarrhea, vomiting, or bleeding, and those presenting late to the treatment center. Early case identification (survivors 3 ± 2 days, non-survivors 5 ± 2 days) due to effective contact tracing by epidemiologists/trainee epidemiologists, as well as prompt suspected case evaluation/isolation achieved containment within 2 months.