In vitro and ex vivo vanadium antitumor activity in (TGF-β)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients
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- 作者：Savvas Petanidisa ; spetanid@auth.gr" class="auth_mail" title="E-mail the corresponding author ; Efrosini Kioseogloua ; efi.kioseoglou@auth.gr" class="auth_mail" title="E-mail the corresponding author ; Kalliopi Domvrib ; kellybio4@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Paul Zarogoulidisb ; pzarog@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Jon M. Carthyc ; jon.carthy@licr.uu.se" class="auth_mail" title="E-mail the corresponding author ; Doxakis Anestakisd ; e ; anestaki@auth.gr" class="auth_mail" title="E-mail the corresponding author ; Aristidis Moustakasc ; f ; aris.moustakas@imbim.uu.se" class="auth_mail" title="E-mail the corresponding author ; Athanasios Salifogloua ; salif@auth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vanadium ; TGF-β ; Epithelial mesenchymal transition ; Cancer stem cells ; Antitumor activity synergism
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：121-134
- 全文大小：4348 K
文摘
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Inhibition of (TGF-β)-mediated EMT by vanadium.
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Reduction of mitochondrial Δψm in malignant cells triggers EMT blockade.
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Ex vivo down-regulation of CD24/CD44/CD133 CSC markers in cancer patients.
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Synergism between vanadium and carboplatin triggers G0/G1 cell cycle arrest.
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Synergistic mechanism sensitizes tumor cells to carboplatin-induced apoptosis.