文摘
New azepino[4,3-b]indol-1(2H)-one derivatives were synthesized as anti-Alzheimer agents. Compound 12b proved to be very potent as inhibitor of human BChE (IC50 = 13 nM). At micromolar concentrations, 12b showed protective effects against NMDA in SH-SY5Y cells. At the active doses, 12b did not exhibit cytotoxicity on liver HepG2 cells.