Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride

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• 作者：K.-H. Lam^a ; K.K.-H. Lee^b ; S.H.-L. Kok^b ; R.S.-M. Wong^c ; F.-Y. Lau^c ; G.Y.-M. Cheng^d ; W.-Y. Wong^e ; S.-W. Tong^c ; K.-W. Chan^c ; R.Y.-K. Chan^f ; J.C.-O. Tang^a ; ^{bccotang@polyu.edu.hk" class="auth_mail" title="E-mail the corresponding author} ; C.-H. Cheng^a ; D.K.-P. Hau^f ; Z.-X. Bian^f ; ^{bzxiang@hkbu.edu.hk" class="auth_mail" title="E-mail the corresponding author} ; R. Gambari^g ; ^{gam@unife.it" class="auth_mail" title="E-mail the corresponding author} ; C.-H. Chui^a ; ^c ; ^f ; ^{chchui@hkbu.edu.hk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：2-Formyl-8-hydroxy-quinolinium chloride ; Antiangiogenesis ; Antitumour ; Diethylnitrosamine-induced hepatocarcinogenesis ; Hepatoma xenograft
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：80
• 期：Complete
• 页码：145-150
• 全文大小：1410 K

文摘

Tumour growth is closely related to the development of new blood vessels to supply oxygen and nutrients to cancer cells. Without the neovascular formation, tumour volumes cannot increase and undergo metastasis. Antiangiogenesis is one of the most promising approaches for antitumour therapy. The exploration of new antiangiogenic agents would be helpful in antitumour therapy. Quinoline is an aromatic nitrogen compound characterized by a double-ring structure which exhibits a benzene ring fused to pyridine at two adjacent carbon atoms. The high stability of quinoline makes it preferable in a variety of therapeutic and pharmaceutical applications, including antitumour treatment. This work is to examine the potential antiangiogenic activity of the synthetic compound 2-Formyl-8-hydroxy-quinolinium chloride. We found that 2-Formyl-8-hydroxy-quinolinium chloride could inhibit the growth of human umbilical vein endothelial cells in vitro. Using the diethylnitrosamine-induced hepatocarcinogenesis model, 2-Formyl-8-hydroxy-quinolinium chloride showed strong antiangiogenic activity. Furthermore, 2-Formyl-8-hydroxy-quinolinium chloride could inhibit the growth of large Hep3B xenografted tumour from the nude mice. We assume that 2-Formyl-8-hydroxy-quinolinium chloride could be a potential antiangiogenic and antitumour agent and it is worthwhile to further study its underlying working mechanism.