Isolation and identification of antibacterial neo-compounds from the red ants of ChangBai Mountain, Tetramorium sp.

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• 作者：Zheng-Wei Song ; Pu Liu ; Wei-Ping Yin ; ^{yinwp@mail.haust.edu.cn} ; Ya-Ling Jiang ; Yun-lai Ren
• 关键词：The red ants of ChangBai Mountain ; Tetramorium sp. ; Antibacterial neo-compounds ; Structural elucidation ; Antibacterial activity ; Insect chemistry
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：15 March, 2012
• 年：2012
• 卷：22
• 期：6
• 页码：2175-2181
• 全文大小：754 K

文摘

Three novel coumarin compounds along with two known amide alkaloids were isolated from a methanol extract of the red ants of ChangBai Mountain, Tetramorium sp. Their structures were identified on the basis of IR, 2D NMR (¹H-¹H COSY, HSQC, HMBC and NOESY) and HRESIMS analysis. Antibacterial activity of all the compounds was evaluated using KB paper diffusion through measurement of inhibiting zone. It was found that four of all the compounds exhibited significant inhibitory activity against Gram-positive bacteria Bacillus subtilis with MIC values of 25 ¦Ìg/ml (compounds 1-3) and 15 ¦Ìg/ml (compound 4).