Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis
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- 作者：Konstantinos Z. Vardakasa ; b ; k.vardakas@aibs.gr" class="auth_mail" title="E-mail the corresponding author ; Kyriakos K. Trigkidisa ; Eleni Boukouvalac ; Matthew E. Falagasa ; b ; d
- 关键词：Clostridium difficile ; Diarrhoea ; Colitis ; Antibiotics
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：48
- 期：1
- 页码：1-10
- 全文大小：1878 K
文摘
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We evaluated the risk for CDI development according to major antibiotic classes by analyzing data from RCTs.
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Only a minority of the selected RCTs (79/1332; 5.9%) reported CDI episodes.
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Carbapenems were associated with more CDIs than fluoroquinolones and cephalosporins.
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Cephalosporins were associated with more CDIs than penicillins and fluoroquinolones.
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Clindamycin was associated with more CDIs than cephalosporins and penicillins.