Ten-day empirical sequential or concomitant therapy is more effective than triple therapy for Helicobacter pylori eradication: A multicenter, prospective study

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• 作者：Jun-Won Chung^a ; ¹ ; Jae Pil Han^c ; ¹ ; Kyoung Oh Kim^a ; Su Young Kim^a ; Su Jin Hong^c ; Tae Ho Kim^d ; Chang Whan Kim^d ; Joon Sung Kim^e ; Byung-Wook Kim^e ; ^{bleok@naver.com" class="auth_mail" title="E-mail the corresponding author} ; Byoung Wook Bang^b ; Hyung Gil Kim^b ; ^{kimhg@inha.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Sung-Cheol Yun^f ; Incheon ; Western Kyonggi Gastrointestinal Study Group
• 关键词：Antibiotic resistance ; Clarithromycin ; Helicobacter pylori ; Metronidazole
• 刊名：Digestive and Liver Disease
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：48
• 期：8
• 页码：888-892
• 全文大小：415 K

文摘

The resistance of Helicobacter pylori to antibiotics has increased the need for new empirical, first-line treatments. However, the efficacy of sequential therapy (ST) and concomitant therapy (CT) compared with triple therapy (TT) has not been adequately evaluated.

Aim

In this study, we evaluated the efficacy of these empirical three regimens.

Methods

The 517 patients enrolled in the study were prospectively randomized to receive 10 days of TT (n = 171), ST (n = 170), and CT (n = 176) at 5 university-affiliated hospitals from May 2013 to March 2015. The post-treatment H. pylori status was determined using the ¹³C-urea breath test.

Results

The baseline characteristics were similar among the three groups. The intention-to-treat eradication rates were 62.6%, 70.6%, and 77.8% in the TT, ST, and CT groups, respectively (p < 0.01). The corresponding per-protocol eradication rates were 82.8%, 89.5%, and 94.4%, respectively (p < 0.01). There were no significant differences in the compliance, side effects, and follow-up loss rates.

Conclusion

A higher eradication rate was achieved with empirical 10-day ST, and CT than with the TT regimen, with similar rates of compliance and treatment side effects.