Characterization and application of two RANK-specific antibodies with different biological activities
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- 作者：Mé ; lanie Chyprea ; b ; Jonathan Seamanc ; Olga G. Cordeiroa ; Laure Willend ; Kathryn A. Knoope ; Andrew Buchananc ; Richard C.A. Sainsonc ; Ifor R. Williamse ; Hideo Yagitaf ; Pascal Schneiderd ; Christopher G. Muellera ; c.mueller@ibmc-cnrs.unistra.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：RANK ; Receptor Activator of NF-κB ; OPG ; osteoprotegerin ; scFv ; single-chain variable fragment ; M cells ; microfold cells
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：171
- 期：Complete
- 页码：5-14
- 全文大小：2311 K
文摘
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Two RANK (TNFRSF11a)-specific monoclonal antibodies are characterized.
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Both recognize human and mouse RANK with high specificity and affinity.
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They are distinct by affinity and interference with receptor-ligand binding.
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Human Langerhans cells highly express RANK.
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The agonist antibody stimulates intestinal microfold cells in vivo.