The immunogenicity in healthy infants and efficiency to prevent mother to child transmission of Hepatitis B virus of a 10 μg recombinant yeast-derived Hepatitis B vaccine (Hep-KSC)
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- 作者：Feng-Cai Zhua ; 1 ; Kui-Xia Sunb ; 1 ; Hong-Xing Pana ; Zhong-Hua Yange ; Ying Lub ; Zheng-Lun Liangc ; Xiao-Feng Liangd ; Fu-Zhen Wangd ; Ying Zenge ; zengyingsz@163.com" class="auth_mail" title="E-mail the corresponding author ; Jie Lib ; jieli@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HBV ; hepatitis B virus ; HepB ; hepatitis B vaccine ; HBIG ; hepatitis B immunoglobulin ; HBsAg ; hepatitis B surface antigen ; GMC ; geometric mean concentration ; Anti-HBs ; antibodies to HBsAg ; NM ; mothers negative for HBsAg/HBeAg/anti-HBe/anti-HBc ; PM ; HBsAg-positive mothers ; HepB-SCY ; hepatitis B vaccine made by recombinant deoxyribonucleic acid techniques in Saccharomyces cerevisiae Yeast ; HepB-KSC ; Kangtai HepB-SCY ; EP ; HBeAg-positive ; EN ; HBeAg-negative ; CI ; confidence intervals ; HBV MTCT ; HBV mot
- 刊名：Vaccine
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：34
- 期：24
- 页码：2656-2662
- 全文大小：1301 K
文摘
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A large-scale randomized controlled trial was conducted.
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Immunogenicity of 10 μg Hep-KSC paralleled Engerix-B and outperformed 5 μg Hep-KSC.
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Equal efficacy in preventing HBV MTCT was observed for 10 μg HepB-KSC and Engerix-B.
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Extensive application of 10 μg Hep-KSC in neonatal immunization might be rational.