Accuracy of FDG-PET/CT and paraneoplastic antibodies in diagnosing cancer in paraneoplastic neurological syndromes

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• 作者：B. Vatankulu^a ; ^{bvatankulu@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; S. Yilmaz Aksoy^b ; S. Asa^a ; S. Sager^a ; H.B. Sayman^a ; M. Halac^a ; K. Sonmezoglu^a
• 关键词：Paraneoplastic neurological syndrome ; Positron emission tomography ; Malignancy ; Paraneoplastic antibodies
• 刊名：Revista Española de Medicina Nuclear e Imagen Molecular
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：35
• 期：1
• 页码：17-21
• 全文大小：455 K

文摘

There is still no consensus about whether to perform PET/CT to detect carcinoma in paraneoplastic neurological syndromes (PNS) in patients with or without antibodies. The aim of this study is to determine the diagnostic accuracy of PET/CT and antibodies in patients with PNS.

Material and Methods

A retrospective study was conducted on patients with clinically suspected PNS between 2008 and 2013. The association between histopathological findings, paraneoplastic antibodies, and PET/CT findings were evaluated. Sensitivity and specificity for the detection of underlying malignancy were calculated for PET/CT and paraneoplastic antibodies.

Results

A total of 42 patients were analyzed. Of these 42 patients, 32 (75%) had a classical PNS, 6 (14%) had positive PET/CT findings, and 34 were tested for the presence of antibodies (anti-Hu Ab, anti-Yo Ab, and anti-Ri Ab). Twenty one of 34 patients had positive antibodies. Of the 6 patients with positive PET/CT findings, 6 had positive histopathological results. Among 21 patients with positive biomarkers, carcinoma was confirmed only in 5 patients. One patient with negative antibodies, but positive PET/CT findings, was diagnosed with a tumor. Gastric carcinoma was detected in 1 patient with negative PET/CT findings and antibodies during follow-up. Based on the results, PET/CT was found to have 85.71% sensitivity, 100% specificity, 100% positive and 97.22% negative predictive values in the detection of tumors.

Conclusion

PET/CT has a certain diagnostic accuracy for detecting underlying malignancy in patients with PNS, regardless of the presence of paraneoplastic antibodies.