The role of Fc-receptors in the uptake and transport of therapeutic antibodies in the retinal pigment epithelium
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- 作者：Michaela Dithmera ; Kirsten Hattermannb ; Prasti Pomariusa ; Shereen Hassan Aboul Nagaa ; c ; Tim Meyerd ; Rolf Mentleinb ; Johann Roidera ; Alexa Klettnera ; aklettner@auge.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Retinal pigment epithelium (RPE) ; Bevacizumab ; Aflibercept ; Rituximab ; Neonatal Fc-receptor (FcRn)
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：187-205
- 全文大小：13074 K
文摘
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Uptake in the retinal pigment epithelium is a general feature of Fc-fragment containing molecules.
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FcRn interacts with myosin7a.
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Intracellular transport may be mediated via myosin7a on actin filaments.
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IgG is transported through the RPE/choroid.
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FcRn may be involved in IgG recycling.