Antibodies raised against divalent type b flagellin and pilin provide effective immunotherapy against Pseudomonas aeruginosa infection of mice with burn wounds

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• 作者：Mahmood Saffari^a ; Somayeh Behbood^a ; ^{somayehbehbood@gmail.com} ; Gholamreza Irajian^b ; Ahmad Khorshidi^a ; Rezvan Moniri^a ; Bahador Behrouz^c ; ^{bahador.behroz3@gmail.com}
• 关键词：Pseudomonas aeruginosa ; Flagellin b ; PilA ; Antibodies ; Murine burn model
• 刊名：Biologicals
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：45
• 期：Complete
• 页码：20-26
• 全文大小：906 K
• 卷排序：45

文摘

This is the first report of protective efficacy of antibodies to flagellin b + PilA. Antibodies against flagellin b + PilA decrease the invasiveness of PA. Antibodies against flagellin b + PilA increase opsono-phagocytic killing of PA. Antibodies against flagellin b + PilA increase the survival of infected mice.