Influenza A virus hemagglutinin specific antibodies interfere with virion neuraminidase activity via two distinct mechanisms
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- 作者：Ivan Kosik ; Jonathan W. Yewdell
- 关键词：Influenza ; ELLA ; TBAA ; HA antibodies ; Canonical antigenic sites ; NA inhibition
- 刊名：Virology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：500
- 期：Complete
- 页码：178-183
- 全文大小：699 K
- 卷排序：500
文摘
Anti-HA antibodies inhibit NA activity by two distinct mechanisms: Blocking binding of virus to surface bound NA-substrate. Sterically inhibiting NA access to large substrates, either in solution or when immobilized. To avoid interference from anti-HA antibodies, ELLA must use either detergent treated virus to dissociate glycoproteins or virus with serum-mismatched HA.