The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor
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- 作者：Natalia Girolaa ; Alisson L. Matsuob ; Carlos R. Figueiredoa ; Mariana H. Massaokaa ; Camyla F. Fariasa ; Denise C. Arrudac ; Ricardo A. Azevedod ; Hugo P. Monteiroe ; Pedro T. Resende-Laraf ; Rodrigo L.O.R. Cunhag ; Luciano Polonellih ; Luiz R. Travassosa ; i ; luiztravassos@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antitumor peptides ; Antibody CDRs ; Melanoma ; Cell migration ; Metastasis ; Hsp90 ; G-protein coupled receptor
- 刊名：Peptides
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：1-15
- 全文大小：4023 K
文摘
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Rb9 is a flexible, hairpin forming, cyclic peptide, with an exposed disulfide bridge.
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Rb9 but not the analogous linear Rb10, forms an α–helix stabilized by H-bonds.
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Tumor cells hyperadherence and migration inhibition are cysteine-linked Rb9 effects.
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Rb9 attenuates Hsp90 chaperone functions and activates adherence GPCR signaling.
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Rb9 is a strong evidence of the bioactivity of isolated immunoglobulin CDR peptides.