Homology modeling of a Camelid antibody fragment against a conserved region of Acinetobacter baumannii biofilm associated protein (Bap)
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- 作者：Fateme Sefida ; Iraj Rasoolia ; b ; rasooli@shahed.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Zahra Payandeha
- 关键词：VHH ; Acinetobacter baumannii ; Biofilm associated protein ; Single-domain antibody
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：21 May 2016
- 年：2016
- 卷：397
- 期：Complete
- 页码：43-51
- 全文大小：1260 K
文摘
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Homology modeling of a VHH against conserved region of A. baumannii Bap was studied.
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Important VHH 3D structure residues and its clefts, ligand binding site were studied.
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Binding modes between Bap as an antigen and the VHH as an antibody were predicted.
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Amino acids involved in antigen-VHH interactions were identified.
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Functional residues in the largest cleft acting in ligand binding were identified.