Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties
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- 作者：Vittorio Canalea ; Rafał Kurczabb ; Anna Partykac ; Grzegorz Satałab ; Tomasz Lendad ; Magdalena Jastrzębska-Więsekc ; Anna Wesołowskac ; Andrzej J. Bojarskib ; Paweł Zajdela ; pawel.zajdel@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Screening of combinatorial library ; Molecular docking ; 5-HT7 antagonist ; SB-269970 ; Forced swim test ; Tail suspension test ; Four plate test ; Depression ; Anxiety
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：334-346
- 全文大小：2614 K
文摘
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Novel arylsulfonamide/amide/urea derivatives of alicyclic amines.
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Application of virtual combinatorial library-virtual screening protocol for compound selection.
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Solid-supported synthesis of 39-membered library.
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Identification of potent and selective 5-HT7 receptors antagonists.
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Antidepressant and anxiolytic properties of 5-HT7 receptors antagonists.