Kynurenine 3-monooxygenase deficiency changes the contents of kynurenine pathways metabolites in the serum and hippocampus.
Kynurenine 3-monooxygenase knockout mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Kynurenine 3-monooxygenase knockout mice is good validities for mouse model of major depressive disorder.