Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina

详细信息    查看全文

• 作者：II Ezeigbo ; ^{ihechi.ezeigbo@yahoo.com} ; ^{ezeigbo.ihechiluru@mouau.edu.ng} ; MI Ezeja ; KG Madubuike ; DC Ifenkwe ; IA Ukweni ; NE Udeh ; SC Akomas
• 关键词：Rauwolfia serpentina ; Castor oil ; Antidiarrhoeal activity ; Intestinal transit
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：2
• 期：6
• 页码：430-432
• 全文大小：248 K

文摘

Objective

To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina (R. serpentina) in experimental diarrhoea induced by castor oil in mice.

Methods

Doses of 100, 200 and 400 mg/kg R. serpentina leaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal activity.

Results

All doses of the extract and the reference drug atropine sulphate (3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl (5 mg/kg, p.o.).

Conclusions

The results show that the extract of R. serpentina leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.