In silico prediction and in vivo analysis of antiestrogenic potential of 2-isopropylthioxanthone (2-ITX) in juvenile goldfish (Carassius auratus)
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- 作者：Paolo Cocci ; paolo.cocci@unicam.it" class="auth_mail" title="E-mail the corresponding author ; Matteo Mozzicafreddo ; Mauro Angeletti ; Gilberto Mosconi ; Francesco Alessandro Palermo
- 关键词：Endocrine disruption ; Gene transcription ; Vitellogenin ; Carassius auratus ; Docking simulation
- 刊名：Ecotoxicology and Environmental Safety
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：202-210
- 全文大小：2273 K
文摘
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An in silico and in vivo approach to assay the antiestrogenicity of 2-ITX.
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The 2-ITX/ERα1 complex was more stable in the inactivation receptor conformation.
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2-ITX reduced the in vivo effects of E2 at both mRNA and protein levels.
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We suggest the presence of a cross-talk between the ERα- and AhR-signaling pathways.