Development and targeting of transcriptional regulatory network controlling FLU1 activation in Candida albicans for novel antifungals
详细信息 查看全文
- 作者：Anubhuti Jha ; Awanish Kumar ; Ph.D ; drawanishkr@gmail.com" class="auth_mail" title="E-mail the corresponding author ; awanik.bt@nitrr.ac.in" class="auth_mail" title="E-mail the corresponding author (Assistant Professor)
- 关键词：Candida albicans ; FLU1 ; Regulatory networks ; Drug resistance ; Antifungals
- 刊名：Journal of Molecular Graphics and Modelling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：1-7
- 全文大小：1660 K
文摘
- •
FLU1 (Major Facilitator Superfamily transporter) has vital role in azole resistance.
- •
We developed a network of TFs for understanding the regulation of FLU1.
- •
9 Antifungals significantly docking with transcription factor (TF) GCN4.
- •
These antifungals have also shown promising result in ADMET studies.
- •
This in silico study gives a platform to improve therapeutics against resistance.