TSGP4 from Ornithodoros moubata: molecular cloning, phylogenetic analysis and vaccine efficacy of a new member of the lipocalin clade of cysteinyl leukotriene scavengers
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- 作者：R. Manzano-Romá ; n raul.manzano@irnasa.csic.es" class="auth_mail" title="E-mail the corresponding author ; V. Dí ; az-Martí ; n veronicadiazmartin@gmail.com" class="auth_mail" title="E-mail the corresponding author ; A. Oleaga ana.oleaga@irnasa.csic.es" class="auth_mail" title="E-mail the corresponding author ; P. Obolo-Mvoulouga prosper.obolo@irnasa.csic.es" class="auth_mail" title="E-mail the corresponding author ; R. Pé ; rez-Sá ; nchez ; ricardo.perez@irnasa.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ornithodoros moubata ; Lipocalin ; TSGP4 ; Recombinant antigens ; Vaccines
- 刊名：Veterinary Parasitology
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：227
- 期：Complete
- 页码：130-137
- 全文大小：1612 K
文摘
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Novel O. moubata TSGP4 salivary lipocalin was cloned and characterized.
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OmTSGP4 belongs to the clade of cysteinyl leukotrienes scavenger in soft ticks.
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Native OmTSGP4 is not immunogenic by natural tick-host contact.
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Vaccination with recombinant OmTSGP4 induces strong responses but low protection.
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OmTSGP4 is a salivary silent antigen.