Pretreatment with antineoplastic and pro-differentiating agents may enhance PDT response.
Three applications of calcipotriol, 5FU and imiquimod creams were applied before MAL-PDT.
MAL-PDT significantly delayed UV-induced skin tumor onset in hairless mice.
Tumor development was not further delayed by pretreatment compared to PDT alone.
Long-term topical pharmacological pretreatment may hold potential to enhance PDT.