A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice
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- 作者：Keita Yamauchia ; b ; &dagger ; ; yamauchi.yakkou@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yusuke Nakanoa ; &dagger ; ; nakano.yakkou@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Takahiko Imaia ; imai.yakkou@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Toshinori Takagia ; c ; to-takagi@hyo-med.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kazuhiro Tsurumaa ; tsuruma@gifu-pu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masamitsu Shimazawaa ; shimazawa@gifu-pu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Toru Iwamab ; tiwama@gifu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hideaki Haraa ; hidehara@gifu-pu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; AREs ; antioxidant-response elements ; BARD ; bardoxolone methyl ; CCA ; common carotid artery ; HO-1 ; heme oxygenase-1 ; IRI ; ischemia&ndash ; reperfusion injury ; Keap-1 ; Kelch-like ECH-associated protein 1 ; MCAO ; middle cerebral artery occlusion ; NF-κB ; nuclear factor-kappa B ; NQO-1 ; NADPH quinone oxidoreductase-1 ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; PBS ; phosphate-buffered saline ; ROS ; reactive oxygen species ; rt-PA ; recombinant tissue plasminogen activator
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：333
- 期：Complete
- 页码：302-310
- 全文大小：1332 K
文摘
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A novel Nrf2 activator, RS9, protected the brain from ischemia–reperfusion injury.
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The efficacy of post-onset treatment is because of rapid Nrf2 activation by RS9.
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RS9 attenuated not only oxidative stress but also neuroinflammation.
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RS9 protected the brain in both the acute and sub-acute phase of ischemia.