Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats
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- 作者：Araceli Diaz-Ruiza ; Ernesto Roldan-Valadezb ; Alma Ortiz-Platac ; Rodrigo Mondragó ; n-Lozanod ; Yessica Heras-Romeroe ; Marisela Mendez-Armentac ; Laura Osorio-Ricoa ; Concepció ; n Nava-Ruizc ; Camilo Rí ; osa ; f ; crios@correo.xoc.uam.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADC ; apparent diffusion coefficient ; ARE ; Antioxidant responsive element ; ATP ; Adenosine Triphosphate ; DAHK ; L-Asp-Ala-His-Lys ; DCF ; 2&prime ; 7&prime ; -dichlorofluorescein ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; DTI ; Diffusion Tensor Imaging ; DWI ; diffusion-weighted imaging ; ECA ; External carotid artery ; FA ; fractional anisotropy ; I/R ; Ischemia reperfusion ; ICA ; Internal carotid artery ; MCA ; middle cerebral artery ; MPO ; Myeloperoxidase ; MRI ; magnetic resonance image ; NMD
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：384-392
- 全文大小：3808 K
文摘
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Dapsone promotes functional improvement after cerebral ischemia and reperfusion.
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Dapsone decreases tissue damage and regulates oxidative stress.
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Neuroprotective effect of dapsone is evident by imaging parameters using a 3 T clinical MR scanner.
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DTI-derived fractional anisotropy is a reliable biomarker of ischemic brain injury in rats.