Complement in autoimmune diseases

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• 作者：Pandiarajan Vignesh ; Amit Rawat ; ^{rawatamit@yahoo.com} ; Madhubala Sharma ; Surjit Singh
• 关键词：Complement ; Autoimmunity ; Classical pathway ; Alternative pathway ; Systemic lupus erythematosus ; Henoch Schonlein purpura ; Antiphospholipid syndrome ; ANCA-associated vasculitides
• 刊名：Clinica Chimica Acta
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：465
• 期：Complete
• 页码：123-130
• 全文大小：562 K
• 卷排序：465

文摘

Complement is an important evolutionary conserved element of the innate immune system. Human complement system comprises more than 20 proteins which are present as inactive precursors. Complement is the final effector mediating tissue damage and injury in a host of autoimmune disease. Inherited deficiencies of early complement components lead to a lupus-like manifestations Deficiencies of component of alternative pathway leads to monogenic forms of atypical haemolytic uremic syndrome