Design, synthesis, and antiviral activities of 1,5-benzothiazepine derivatives containing pyridine moiety

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• 作者：Tianxian Li ; Jian Zhang ; Jianke Pan ; Zengxue Wu ; Deyu Hu ; Baoan Song ; ^{songbaoan22@yahoo.com}
• 关键词：Benzothiazepine derivatives ; Pyridine ; 1 ; 3-Dipolar cycloaddition ; Antiviral activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：657-662
• 全文大小：475 K
• 卷排序：125

文摘

Benzothiazepine were synthesized through 1,3-dipolar cycloaddition. Compound 3m exhibited marked curative activity against TMV. Electron-withdrawing groups are in favors of antiviral activity.