Hepatitis C Treatment: Clinical Issues for Psychiatrists in the Post-Interferon Era

详细信息    查看全文

• 作者：Yvonne Chasser ; M.D.^a ; ^d ; ^{ychasser@partners.org} ; Arthur Y. Kim ; M.D.^b ; ^d ; Oliver Freudenreich ; M.D. ; F.A.P.M^c ; ^d
• 关键词：hepatitis C ; epidemiology ; integrated care ; barriers to care ; serious mental illness ; schizophrenia
• 刊名：Psychosomatics
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：58
• 期：1
• 页码：1-10
• 全文大小：254 K
• 卷排序：58

文摘

Hepatitis C virus (HCV) is a widespread and costly cause of morbidity and mortality globally and in the United States. The treatment of HCV has been revolutionized with the recent development of direct-acting antiviral medications. These new treatments are substantially better tolerated and more efficacious than previously used interferon-based therapies. Despite these innovations, sustained virologic response has remained low, hovering at approximately 9% of all infected persons. The reasons for this failure include lack of screening, low rates of linkage to care, cost of direct-acting antivirals, and barriers in access to care for patients. Psychiatrists work with patients at a disproportionately high risk for HCV infection yet many do not currently assume an active role in the HCV epidemic.ObjectiveThe purpose of this clinical review is to familiarize psychiatrists with currently available hepatitis C treatments and discuss the remaining treatment challenges, including the high cost of treatment.MethodsThe authors used information from the Centers for Disease Control and Food and Drug Administration on the most current estimates of HCV epidemiology, risk factors, and approved interferon-free treatments. PUBMED was searched for examples of HCV treatment in community psychiatry settings.ConclusionsThe mental health community is well-positioned to take on a more active role in HCV treatment and engage patients׳ trust in the treatment process. However, many barriers still exist. We encourage psychiatrists to assume a collaborative role in caring for psychiatric patients infected with HCV.