Intranasal delivery of DNA encoding antigens of Mycobacterium tuberculosis by non-pathogenic invasive Escherichia coli
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- 作者：Paola Brun ; Antonella Zumbo ; Ignazio Castagliuolo ; Giovanni Delogu ; Filippo Manfrin ; Michela Sali ; Giovanni Fadda ; Catherine Grillot-Courvalin ; Giorgio Palù ; Riccardo Manganelli
- 关键词：Mycobacterium tuberculosis ; DNA vaccine ; Delivery system ; Live recombinant vaccine ; Tuberculosis
- 刊名：Vaccine
- 出版年：2008
- 出版时间：7 April 2008
- 年：2008
- 卷：26
- 期：16
- 页码：1934-1941
- 全文大小：280 K
文摘
Naturally invasive bacteria have been successfully used for mucosal delivery of DNA vaccines against bacterial, viral and tumour antigens. Recently, an alternative delivery system based on a genetically modified mutant of the non-pathogenic commensal bacterium Escherichia coli, was developed and successfully used to deliver therapeutic genes and immunogenic proteins to epithelial cells in vivo.