A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study
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Mean baseline HADS total, HADS-A and HADS-D subscale scores were within normal.

Mean HADS total, HADS-A or HADS-D subscale scores did not change with time (p > 0.05).

Patients with baseline HADS scores indicating anxiety/depression tended to improve.

HDRS and IES-R total scores improved over time (p < 0.05).

Disease-modifying treatment may improve emotional burden in patients with MS.

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