Mean baseline HADS total, HADS-A and HADS-D subscale scores were within normal.
Mean HADS total, HADS-A or HADS-D subscale scores did not change with time (p > 0.05).
Patients with baseline HADS scores indicating anxiety/depression tended to improve.
HDRS and IES-R total scores improved over time (p < 0.05).
Disease-modifying treatment may improve emotional burden in patients with MS.