Comparative long-term outcomes after cardiac resynchronization therapy in right ventricular paced patients versus native wide left bundle branch block patients

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• 作者：Bhupendar Tayal ; MD^* ; ^&dagger ; ; ^{bhupendar.tayal@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; John Gorcsan III ; MD^* ; Antonia Delgado-Montero ; MD^* ; Akiko Goda ; MD ; PhD^* ; Keiko Ryo ; MD ; PhD^* ; Samir Saba ; MD ; FHRS^* ; Niels Risum ; MD ; PhD^&Dagger ; ; Peter Sogaard ; MD ; DMSc^&dagger ;
• 关键词：CI ; confidence interval ; CRT ; cardiac resynchronization therapy ; EF ; ejection fraction ; HF ; heart failure ; HR ; hazard ratio ; IQR ; interquartile range ; LBBB ; left bundle branch block ; LV ; left ventricle/ventricular ; LVAD ; left ventricular assist device ; MR ; mitral regurgitation ; RAFT ; Resynchronization-Defibrillation for Ambulatory Heart Failure Trial ; RVP ; right ventricular pacing
• 刊名：Heart Rhythm
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：13
• 期：2
• 页码：511-518
• 全文大小：1160 K

文摘

The current guidelines do not clearly state when we should upgrade a patient with right ventricular pacing (RVP) to cardiac resynchronization therapy (CRT), although the deleterious effect of chronic RVP has been established with recent trials.

Objectives

The aims of this study were to compare the long-term survival after CRT in patients upgraded from RVP with that in patients with left bundle branch block (LBBB) with QRS duration ≥ 150 ms and to compare the mechanical properties associated with CRT response in these groups.

Methods

Overall, 135 patients with implanted CRT from a single center (85 (63%) with native wide LBBB and 50 (37%) with RVP) were studied prospectively. Baseline left ventricular typical contraction pattern was determined using speckle tracking echocardiography in the apical 4-chamber view. The predefined end point was death, heart transplantation, or left ventricular assist device implantation over a period of 4 years.

Results

Patients with RVP had a significantly favorable long-term outcomes with adjusted hazard ratio of 0.36 (95% confidence interval 0.14–0.96; P = .04). Both groups had ~70% of patients with typical contraction pattern. The absence of typical contraction pattern was associated with a higher risk of an end point with adjusted hazard ratio of 5.43 (95% confidence interval 2.31–12.72; P < .001). In patients with typical contraction pattern, activation of the apical septal segment occurred more frequently in the RVP group and of the base or mid septal segments in the LBBB group.

Conclusion

Patients with HF upgraded from RVP have more favorable long-term outcomes after CRT than do native LBBB patients with QRS duration ≥ 150 ms. Contraction pattern assessment can be used to identify potential responders in the RVP group.