Nfix Regulates Temporal Progression of Muscle Regeneration through Modulation of Myostatin Expression
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- 作者：Giuliana Rossi1 ; Stefania Antonini1 ; Chiara Bonfanti1 ; Stefania Monteverde1 ; Chiara Vezzali1 ; Shahragim Tajbakhsh2 ; Giulio Cossu1 ; 3 ; Graziella Messina1 ; graziella.messina@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Myostatin ; Nfix ; regeneration ; satellite cells ; skeletal muscle
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：14
- 期：9
- 页码：2238-2249
- 全文大小：6609 K
文摘
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Muscle differentiation is delayed in Nfix-null satellite cells in vitro
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Mice lacking Nfix in satellite cells show delayed regeneration upon injury
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Nfix directly regulates Myostatin expression during regeneration
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In vivo silencing of Myostatin rescues the regeneration deficit in Nfix-null mice