Non-alcoholic fatty liver disease is associated with high prevalence of gastro-oesophageal reflux symptoms

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• 作者：Luca Miele ; ^{luca.miele@rm.unicatt.it} ; Giovanni Cammarota ; Vittoria Vero ; Simona Racco ; Consuelo Cefalo ; Giuseppe Marrone ; Maurizio Pompili ; Gianlodovico Rapaccini ; Alessandro Bianco ; Raffaele Landolfi ; Antonio Gasbarrini ; Antonio Grieco
• 关键词：Fatty liver ; Gastro-oesophageal reflux ; GERD ; Heartburn ; NAFLD ; Regurgitation ; Steatosis ; Symptoms
• 刊名：Digestive and Liver Disease
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：44
• 期：12
• 页码：1032-1036
• 全文大小：315 K

文摘

Background

Gastro-oesophageal reflux symptoms are usually reported by patients with obesity and metabolic syndrome. Aim of this study was to assess the prevalence and clinical characteristics of gastro-oesophageal reflux symptoms in subjects with non-alcoholic fatty liver disease.

Methods

Cross-sectional, case-control study of 185 consecutive patients with non-alcoholic fatty liver disease and an age- and sex-matched control group of 112 healthy volunteers. Participants were interviewed with the aid of a previously validated questionnaire to assess lifestyle and reflux symptoms in the 3 months preceding enrolment. Odds ratios were determined before and after adjustment for body mass index, increased waist circumference, physical activity, metabolic syndrome and proton pump inhibitors and/or antiacid medication.

Results

The prevalence of heartburn and/or regurgitation and of at least one of gastro-oesophageal reflux symptoms was significantly higher in the non-alcoholic fatty liver disease group. Non-alcoholic fatty liver disease subjects were associated to higher prevalence of heartburn (adjusted odds ratios: 2.17, 95 % confidence intervals: 1.16-4.04), regurgitation (adjusted odds ratios: 2.61, 95 % confidence intervals: 1.24-5.48) and belching (adjusted odds ratios: 2.01, 95 % confidence intervals: 1.12-3.59) and had higher prevalence of at least one GER symptom (adjusted odds ratios: 3.34, 95 % confidence intervals: 1.76-6.36).

Conclusion

Non-alcoholic fatty liver disease is associated with a higher prevalence of gastro-oesophageal reflux symptoms.