Colorectal cancer screening in the familial risk population: Is colonoscopy still the strategy of choice?
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- 作者：Antonio Z. Gimeno-Garcí ; a ; antozeben@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Noemi Herná ; ndez-Á ; lvarez-de-Buylla ; David Nicolá ; s-Pé ; rez ; Marta Carrillo ; Goretti Herná ; ndez ; Enrique Quintero
- 关键词：Colonoscopy screening ; Familial risk population ; Colorectal cancer ; Screening uptake
- 刊名：Gastroenterología y Hepatología
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：39
- 期：5
- 页码：352-360
- 全文大小：946 K
文摘
First-degree relatives of patients with colorectal cancer (CRC) are at high risk of this disease. For this reason, medical organizations and clinical guidelines recommend more intensive screening and surveillance for such first-degree relatives than for the average-risk population. Colonoscopy has been the cornerstone of CRC screening in this setting. Although colonoscopy is the most sensitive technique for the detection of neoplastic lesions (especially non-advanced adenomas), its role is less clear for CRC. In addition, screening colonoscopy has several limitations that may affect the success of a screening campaign, such as poor participant acceptance, the need for skilled endoscopists, participant access to screening colonoscopy, overburdened endoscopy units, potential complications, and procedure-related costs. In addition, recent evidence has cast doubt on the advantage of colonoscopy over other strategies for the detection of advanced neoplastic lesions. Despite being less sensitive in general, other screening methods frequently recommended in the average-risk population may be more acceptable and thus help increase CRC screening uptake. This review discusses recent evidence on the risk of CRC in first-degree relatives, the advantages and disadvantages of each screening technique, participation rates depending on the technique, patient preferences, and barriers to screening.