Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target

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• 作者：Veró ; nica Seguel^a ; ³ ; Lorena Castro^a ; ³ ; Chantal Reigada^b ; Leonel Cortes^a ; Marí ; a V. Dí ; az^a ; Mariana R. Miranda^b ; Claudio A. Pereira^b ; Michel Lapier^a ; Carolina Campos-Estrada^a ; ¹ ; Antonio Morello^a ; Ulrike Kemmerling^c ; Juan D. Maya^a ; ⁴ ; Rodrigo Ló ; pez-Muñ ; oz^a ; ² ; ⁴ ; ^{rodrigo.lopez@uach.cl}
• 关键词：Trypanosoma cruzi ; Chagas disease ; Pentamidine ; Benznidazole ; Polyamine transport
• 刊名：Experimental Parasitology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：171
• 期：Complete
• 页码：23-32
• 全文大小：2310 K
• 卷排序：171

文摘

Pentamidine antagonize the anti-T. cruzi effect benznidazole in isolated trypomastigotes and infected cells. Pentamidine lack of synergy with benznidazole in T. cruzi-infected mice. Pentamidine blocks the TcPAT12, but is unable to decrease the trypanothione levels. Overexpression of TcPAT12 doesn't modify the effect of pentamidine.