A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility
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- 作者：Loredana Vecchione1 ; 16 ; Valentina Gambino1 ; 16 ; Jonne Raaijmakers2 ; Andreas Schlicker1 ; Arianna Fumagalli3 ; Mariangela Russo4 ; 5 ; 6 ; Alberto Villanueva7 ; Evelyne Beerling3 ; Alice Bartolini5 ; David G. Mollevi7 ; Nizar El-Murr8 ; Marielle Chiron8 ; Loreley Calvet8 ; Cé ; line Nicolazzi8 ; Cé ; cile Combeau8 ; Christophe Henry8 ; Iris M. Simon9 ; Sun Tian9 ; Sjors in &lsquo ; t Veld9 ; Giovanni D&rsquo ; ario10 ; Sara Mainardi1 ; Roderick L. Beijersbergen1 ; Cor Lieftink1 ; Sabine Linn11 ; Cornelia Rumpf-Kienzl2 ; Mauro Delorenzi10 ; 12 ; 13 ; Lodewyk Wessels1 ; Ramon Salazar14 ; Federica Di Nicolantonio4 ; 5 ; Alberto Bardelli4 ; 5 ; Jacco van Rheenen3 ; René ; H. Medema2 ; Sabine Tejpar15 ; René ; Bernards1 ; r.bernards@nki.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：BRAF-like colon cancer ; functional genomics ; RANBP2 ; vinorelbine ; targeted treatment
- 刊名：Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：165
- 期：2
- 页码：317-330
- 全文大小：3128 K
文摘
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<em>RANBP2em> loss is lethal to <em>BRAFem>-like colon cancer (CC) cells
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<em>BRAFem>-like CC cells have defective microtubule outgrowth from kinetochores
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RANBP2 loss exacerbates the defective microtubules outgrowth in BRAF-like CC cells
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Vinorelbine is selectively toxic to <em>BRAFem>-like colon cancer cells