Omega-6 fatty acids and greater likelihood of suicide risk and major depression in early pregnancy

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• 作者：Juliana S. Vaz ; Gilberto Kac ; Antonio E. Nardi ; Joseph R. Hibbeln
• 关键词：Pregnancy ; Suicide risk ; Major depressive disorder ; Arachidonic acid ; Omega-6 fatty acids
• 刊名：Journal of Affective Disorders
• 出版年：January, 2014
• 年：2014
• 卷：152-154
• 期：Complete
• 页码：76-82
• 全文大小：271 K

文摘

Objective

To estimate the prevalence of suicide risk (SR) and major depressive episodes (MDEs) in early pregnancy, as well as the relationship of serum fatty acid status to these outcomes.

Methods

Cross-sectional analyses were performed on data from 234 pregnant women enrolled in a prospective cohort study in Rio de Janeiro, Brazil. SR and MDE were defined according to the Mini International Neuropsychiatric Interview. Fatty acid compositions were determined for serum samples obtained between the 6th and 13th gestational week. Fatty acid data were expressed as the percent of total fatty acids, converted to Z scores and then entered as continuous variables in logistic regression models.

Results

The prevalence of SR was 19.6% and that of MDE was 17.0%. In the adjusted logistic regressions, a higher likelihood of SR was observed among women with higher arachidonic acid levels [AA (20:4, n-6): OR=1.45, 95%CI 1.02-2.07] and adrenic acid levels [AdA (22:4, n-6): OR=1.43, 95%CI 1.01-2.04]. A higher likelihood of MDE was also observed among women with higher AA levels [OR=1.47, 95%CI 1.03-2.10] and AdA levels [OR=1.59, 95%CI 1.09-2.32].

Conclusion

Higher serum levels of AA and AdA were associated with a greater likelihood of SR and MDE among pregnant Brazilian women.