Mitochondrial fusion proteins: Dual regulators of morphology and metabolism
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- 作者：Antonio Zorzano ; Marc Liesa ; David Sebastiá ; n ; Jessica Segalé ; s ; Manuel Palací ; n
- 关键词：Mitofusin ; OPA1 ; PGC-1α ; PGC-1β ; Mitochondrial metabolism ; Mitochondrial fusion
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：21
- 期：6
- 页码：566-574
- 全文大小：256 K
文摘
Mitochondria in mammalian cells are visualized as a network or as filaments that undergo continuous changes in shape and in localization within the cells. These changes are a consequence of the activity of different processes such as mitochondrial fusion and fission, and mitochondrial remodelling. In all, these processes are referred to as mitochondrial dynamics, and relevant questions, still unexplained, are why cells require such an active dynamics, or why mitochondria move to specific cellular regions. In this review we will summarize some of the biological functions assigned to the proteins identified as participating in mitochondrial fusion, namely mitofusin 1, mitofusin 2 and OPA1. In addition to the capacity of these proteins to promote fusion, mitofusin 2 or OPA1 regulate mitochondrial metabolism and loss-of-function reduces oxygen consumption and the capacity to oxidize substrates. We propose that mitochondrial fusion proteins operate as integrators of signals so they regulate both mitochondrial fusion and metabolism.