DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus

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• 作者：Caroline Mauvezin ; Ana Sancho ; Saska Ivanova ; Manuel Palacin ; Antonio Zorzano
• 关键词：DOR ; diabetes and obesity related protein ; NES ; nuclear export signal ; NPM ; nucleophosmin
• 刊名：FEBS Letters
• 出版年：2012
• 出版时间：21 September, 2012
• 年：2012
• 卷：586
• 期：19
• 页码：3179-3186
• 全文大小：1329 K

文摘

DOR is a bi-functional protein that regulates transcription and enhances starvation-induced autophagy. While autophagy has been mostly described as a stress-response mechanism, cells also need autophagy to maintain homeostasis in basal conditions. However, the mechanisms regulating basal autophagy still remain unknown. Our results show that DOR acts in basal autophagy. Indeed, DOR already undergoes nucleo-cytoplasmic shuttling in basal conditions and, surprisingly, DOR exits continuously the nucleus and traverses the nucleolus. However, the nucleolus integrity is not essential for both DOR nucleo-cytoplasmic shuttling and DOR function on basal autophagy. Taken together, we propose that DOR exit from the nucleus is essential for basal autophagy stimulation even under nucleolus disruption.