Telmisartan improves and PD123319 worsens diabetic nephropathy progression. Telmisartan reduces and PD123319 elevates monocyte infiltration and renal fibrosis. H3 acetylation and H2AK119Ub are increased by PD123319 and reduced by Telmisartan. Telmisartan reduces occupancy of H2AK119Ub at Mcp1 and Tgfb1 promoters.