文摘
From the antiviral activity of twelve amodiaquine derivatives, an interaction pharmacophore model was developed. Based on the model three new antimalarials were identified and verified as potent inhibitors of dengue and Zika viruses. Mode of action of these compounds is through inhibition of autophagy, especially the lysosomal proteases. This current study may lead to repurposing of antimalarial drugs for treatment of flaviviral infections.