ANXA2 enhances the progression of hepatocellular carcinoma via remodeling the cell motility associated structures
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- 作者：Hongyan Shia ; Li Xiaoa ; Wei Duanb ; Huimin Hea ; Lele Maa ; Miaomiao Daa ; Yan Duana ; Qian Wanga ; Huayi Wuc ; Xigui Songc ; Yingchun Houa ; ychhou@snnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANXA2 ; Cell structures ; Cell behaviors ; Hepatocellular carcinoma ; Gene expression
- 刊名：Micron
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：26-33
- 全文大小：3476 K
文摘
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ANXA2 enhances HCC growth by up-regulating cell proliferation without significant apoptosis enhancement.
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ANXA2 enhances the HCC cell motility by up-regulating expression and polymerization of cell microstructure associated proteins, F-actin, β-tubulin and lamin B.
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ANXA2 enhances HCC metastasis by introducing development of the cell psuedopodia/filapodia closely associated with cell motility and contact inhibition.
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Take above together, ANXA2 enhances malignancy of HCC cells by remodeling motility associated microstructures.