Expression and biological activity of two types of interferon genes in medaka (Oryzias latipes)
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- 作者：Shun Maekawaa ; Yi-An Chianga ; Jun-ichi Hikimab ; Masahiro Sakaib ; Chu-Fang Loc ; Han-Ching Wanga ; wanghc@mail.ncku.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Takashi Aokia ; takashi.aoki65@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type I interferon ; ISGs ; PolyI ; C ; NNV ; Antiviral response ; Medaka
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：20-29
- 全文大小：1051 K
文摘
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Two type I interferon genes were identified in medaka.
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They were classified as subgroup-a and -d, respectively.
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Expressions of olIFNs were induced by nervous necrosis virus (NNV) in vivo.
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Overexpression of olIFNs in DIT cells reduced viral copy numbers after NNV infection.