Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats
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- 作者：Uday P. Pratap1 ; Himanshu R. Sharma1 ; Aparna Mohanty ; Prathamesh Kale ; Srinivasan Gopinath ; Lalgi Hima ; Hannah P. Priyanka ; Srinivasan ThyagaRajan ; thyagarajan.s@ktr.srmuniv.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytokine ; Lipid peroxidation ; Inflammation ; Aging ; Free radicals
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：591-598
- 全文大小：1100 K
文摘
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Estrogen mediates inflammatory responses through p-Akt/p-mTOR/p-NF-κB pathways.
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Estrogen increases IFN-γ, TNF-α and NO production through intracellular signaling markers.
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Estrogen increases NF-κB expression suggesting its role in inflammatory responses.
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Estrogen promotes free radical formation as measured through lipid peroxidation.