Biological response of novel high strength-low elastic modulus β-Ti2448 alloy was evaluated. The formation of fine apatite-like crystals in simulated body fluid confirmed the superior bioactivity of the alloy. The unique surface properties of the Ti2448 alloy provided favorable osteogenic microenvironment for cell–material interaction. The β-Ti2448 alloy with a modulus of ∼49 GPa may avoid the undesirable stress-shielding effect.