Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation
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- 作者：Min Zhanga ; 1 ; Liang Lia ; 1 ; Wei Xiea ; 1 ; Jian-Feng Wub ; Feng Yaoa ; Yu-Lin Tana ; Xiao-Dan Xiaa ; Xiao-Yan Liua ; Dan Liua ; Gang Lana ; Meng-Ya Zenga ; Duo Gonga ; Hai-Peng Chenga ; Chong Huanga ; Zhen-Wang Zhaoa ; Xi-Long Zhengc ; Chao-Ke Tanga ; tangchaoke@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIBP ; ABCA1 ; ApoA-1 ; CSN2 ; Ubiquitination ; Cholesterol efflux ; Foam cell ; Atherosclerosis
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：149-159
- 全文大小：2419 K
文摘
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AIBP promotes apoA-1 binding to ABCA1 on the cell membrane of macrophages.
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AIBP prevents ABCA1 from CSN2-mediated degradation to prevent foam cell formation.
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AIBP 115–123 aa is at least partially responsible for its binding to apoA-1.