Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review
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- 作者：Boopathi Subramaniyan ; Kaviya Jagadeesan ; Sabitha Ramakrishnan ; Ganeshan Mathan ; mathan@bdu.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：AKAP ; A-kinase-anchoring proteins ; AML ; Acute myeloid leukemia ; APC ; adenomatous polyposis coli ; APC/C ; anaphase-promoting complex/cyclosome ; ATM ; aataxia-telangiectasia mutated ; ATR ; ataxia telangiectasia-mutated and Rad3-related ; BRCA1 ; breast cancer 1 ; CASP8 ; caspase 8 apoptosis-related cysteine peptidase ; CBP ; CREB-binding protein ; Cdc ; cyclin dependent kinase ; Cdh1 ; cadherin-1 ; CENP-A ; centromere protein A ; Chk1/2 ; checkpoint kinase1/2 ; CK1α ; casine kinase 1 alpha ; CML ; chronic myeloid leuk
- 刊名：Biomedicine & Pharmacotherapy
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：82
- 期：Complete
- 页码：413-424
- 全文大小：2215 K
文摘
The Aurora kinases belong to the family of serine/threonine kinase, a central regulator of mitosis and their expression increased during G2/M phase. It is classified into Aurora A, B and C, each has distinct roles in cellular processes, which includes regulation of spindle assembly, function of centrosomes, cytoskeleton and cytokinesis. During cancer growth, their rapid increase makes most attractive marker for cancer treatment at present. However Aurora A kinase is known to be a marker for cancer therapy, the most important serine/threonine kinase of Aurora B kinase involvement in cancer is still inadequate. Subsequently, the recent findings revealed that the class III histone deacetylase of SIRT1 is a key regulator to activate Aurora kinases from S phase damaged DNA through Wnt signaling pathway. Even if both Aurora A kinase and SIRT1 serve as a marker for cancer therapy, the present review reveals it is interaction in Wnt signaling pathway that solely for colorectal cancer.