Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats

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• 作者：Rihab Aydi^a ; ¹ ; Amel Ben Gara^b ; ¹ ; Rim Chaaben^d ; Hajer Ben Saad^e ; Lotfi Fki^b ; Abdelfattah ElFeki^c ; Hafedh Belghith^f ; Karima Belghith^b ; Majed Kammoun^a ; ^{majed_kammoun@yahoo.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Oxaziridine ; Obesity ; Liver-kidney functions
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：82
• 期：Complete
• 页码：660-668
• 全文大小：2666 K

文摘

Obesity is a serious health problem that increases the risk of many complications, including diabetes and cardiovascular disease. This study aims to evaluate, for the first time, the effects of oxaziridine 3 on lipoprotein lipase activity in the serum of rats fed with a high-fat diet (HFD) on body weight, lipid profile and liver-kidney functions. The administration of oxaziridine 3 to HFD-rats lowered body weight and inhibited the lipase activity of obese rats leading to notable decrease of T-Ch, TGs and LDL-Ch levels accompanied with an increase in HDL-Ch concentration in serum. Moreover, the findings of this study revealed that oxaziridine 3 helped to protect liver tissue from the appearance of fatty cysts. Additionally, oxaziridine 3 administration to HFD-rats induces antioxidant activity proven by the increase of superoxide dismutase (SOD) and catalase (CAT) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels. It also induces the protection of liver-kidney functions confirmed by a decrease in the levels of toxicity parameters in blood.