Phenotype of blasts in chronic myeloid leukemia in blastic phase—Analysis of bone marrow trephine biopsies and correlation with cytogenetics

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• 作者：Alistair G. Reid ; Valeria A. De Melo ; Kay Elderfield ; Ian Clark ; David Marin ; Jane Apperley ; Kikkeri N. Naresh
• 关键词：Chronic myeloid leukemia ; Blast crisis ; Accelerated phase ; Bone marrow trephine biopsy
• 刊名：Leukemia Research
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：33
• 期：3
• 页码：418-425
• 全文大小：1895 K

文摘

We identified different phenotypic subsets among 62 cases of chronic myeloid leukemia (CML) in blast crisis (BC) (26 % B-lymphoblastic, and 74 % various myeloblastic subsets) on bone marrow trephines and correlated the blast-phenotype with cytogenetics. Five of myeloid-BC had an associated 3q26 abnormality and two of these showed a megakaryoblastic-phenotype. While myeloid-BC was associated with additional copies of Philadelphia (Ph) (29 % ) (p = 0.08), numerical abnormalities (51 % ) (p = 0.007), trisomy-8 (29 % ) (p = 0.08) and 17p-loss (22 % ), none of lymphoid-BC showed these abnormalities. Among myeloid-BC, CD34-negative cases were more often associated with trisomy-8, 17p-loss and numerical abnormalities, and the CD117-negative subset with additional copies of Ph (p < 0.05).